6-溴-2-(呋喃-2-基)[1,2,4]噻唑并[1,5-a]吡嗪-8-胺合成路线 （共 5 条）
反应条件
ammonia in 1,4-dioxane
T=20°C; 49 h;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2004/92177 A1, 2004 ;
Location in patent: Page 27 ;
WO 2004/092177 A1
反应条件
ammonia in 1,4-dioxane
T=10 - 20°C; 0.5 h;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2004/92177 A1, 2004 ;
Location in patent: Page 29-30 ;
WO 2004/092177 A1
反应条件
1: in methanol
T=70°C; 5 h;
2: With ammonia in 1,4-dioxane
T=20°C;
参考文献
Yao, Gang; Haque, Serajul; Sha, Li; Kumaravel, Gnanasambandam; Wang, Joy; Engber, Thomas M.; Whalley, Eric T.; Conlon, Patrick R.; Chang, Hexi; Kiesman, William F.; Petter, Russell C.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 511 - 515
反应条件
1: 40 percent / Pb(OAc)4 / toluene / 2 h / 115 °C
2: NH3 / dioxane
View Scheme
参考文献
Dowling, James E.; Vessels, Jeffrey T.; Haque, Serajul; He, Xi Chang; Van Vloten, Kurt; Kumaravel, Gnanasambandam; Engber, Thomas; Jin, Xiaowei; Phadke, Deepali; Wang, Joy; Ayyub, Eman; Petter, Russell C.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4809 - 4813
反应条件
1: 70 percent / AlCl3 / 1,2-dichloro-ethane / Heating
2: 40 percent / Pb(OAc)4 / toluene / 2 h / 115 °C
3: NH3 / dioxane
View Scheme
参考文献
Dowling, James E.; Vessels, Jeffrey T.; Haque, Serajul; He, Xi Chang; Van Vloten, Kurt; Kumaravel, Gnanasambandam; Engber, Thomas; Jin, Xiaowei; Phadke, Deepali; Wang, Joy; Ayyub, Eman; Petter, Russell C.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4809 - 4813
