9-[4-(4,4,5,5-四甲基-1,3,2-二氧硼杂环戊烷-2-基)苯基]-9H-咔唑合成路线 （共 10 条）
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; palladium diacetate in dimethyl sulfoxide
T=80°C; 8 h; Inert atmosphere;
参考文献
Chen, Bo; Ding, Junqiao; Wang, Lixiang; Jing, Xiabin; Wang, Fosong
Chemical Communications, 2012 , vol. 48, # 71 p. 8970 - 8972
反应条件
1: 9-(4-bromophenyl)carbazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane
cooling;
参考文献
Sun, Yi-Heng; Zhu, Xu-Hui; Chen, Zhao; Zhang, Yong; Cao, Yong
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 6281 - 6284
反应条件
boron trifluoride diethyl etherate in acetonitrile
T=0 - 20°C; 0.5 h; Inert atmosphere;
参考文献
Zhu, Chuan; Yamane, Motoki
Organic Letters, 2012 , vol. 14, # 17 p. 4560 - 4563
参考文献
Gough, Neil; Tsai, Ethan
Patent: US2011/245429 A1, 2011 ;
反应条件
1.1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 8 h / Reflux; Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -70 - 40 °C / Inert atmosphere
2.2: 7 h / -70 - 20 °C
View Scheme
参考文献
YU, Eun-Sun; KIM, Nam-Soo; KIM, Young-Hoon; CHAE, Mi-Young; KANG, Eui-Su
Patent: US2012/280221 A1, 2012 ;
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
1.2: 0.5 h / 0 - 20 °C
2.1: boron trifluoride diethyl etherate / acetonitrile / 0.5 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Zhu, Chuan; Yamane, Motoki
Organic Letters, 2012 , vol. 14, # 17 p. 4560 - 4563
反应条件
1: K3PO4; CuI; trans-1,2-diaminocyclohexane / toluene / Heating
2: n-BuLi / tetrahydrofuran / -78 °C
View Scheme
参考文献
Jeon, Ji Young; Park, Tae Jin; Jeon, Woo Sik; Park, Jung Joo; Jang, Jin; Kwon, Jang Hyuk; Lee, Jae Yeol
Chemistry Letters, 2007 , vol. 36, # 9 p. 1156 - 1157
反应条件
1: potassium carbonate; copper / N,N-dimethyl-formamide / 42 h / 130 °C / Inert atmosphere
2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 67 h / 80 °C / Inert atmosphere
View Scheme
参考文献
NITTO DENKO CORPORATION; SISK, David, T.; KHAN, Sazzadur, Rahman; MOCHIZUKI, Amane
Patent: WO2012/37269 A1, 2012 ;
反应条件
1.1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 8 h / Reflux; Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -70 - 40 °C / Inert atmosphere
2.2: 7 h / -70 - 20 °C
View Scheme
参考文献
YU, Eun-Sun; KIM, Nam-Soo; KIM, Young-Hoon; CHAE, Mi-Young; KANG, Eui-Su
Patent: US2012/280221 A1, 2012 ;
参考文献
Song, Mi-Seon; Nguyen, Quynh Pham Bao; Song, Chang-Hyun; Lee, Duckhee; Chai, Kyu Yun
Molecules, 2013 , vol. 18, # 11 p. 14033 - 14041
