(S)-(-)-5-羟甲基-2(5H)-呋喃酮合成路线 （共 46 条）
反应条件
1: 100 percent / conc. aq. HCl / ethanol / 22 h / Ambient temperature 2: 81 percent / 30percent aq. H2O2 / acetic acid / 2 h / Ambient temperature 3: CaCO3 / toluene / 3 h / Heating View Scheme
参考文献
Synthesis, , # 5 p. 403 - 406
反应条件
1: NaHSO3 / propan-2-ol / 72 h / Ambient temperature 2: 0.5M HCl / methanol / 18 h / 5 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 20 p. 2299 - 2300
反应条件
1: 1.)t-BuMe2SiCl; 2.) SOCl2, pyridine / 1.) CH2Cl2, 20 deg C., 16h; 2.) CH2Cl2, 24 deg C, 22h 2: 82 percent / H2O, AcOH / tetrahydrofuran / 22 h / 24 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 22 p. 2489 - 2490
反应条件
1: K2CO3 / methanol / 1 h 2: pyridine, dimethylaminopyridine / CH2Cl2 / 1 h 3: 40percent aq. AcOOH / 12 h View Scheme
参考文献
Heterocycles, , vol. 36, # 1 p. 149 - 155
反应条件
1: pyridine, dimethylaminopyridine / CH2Cl2 / 1 h 2: 40percent aq. AcOOH / 12 h View Scheme
参考文献
Heterocycles, , vol. 36, # 1 p. 149 - 155
反应条件
1: 87 percent / BF3*Et2O / CH2Cl2 / 72 h 2: K2CO3 / methanol / 1 h 3: pyridine, dimethylaminopyridine / CH2Cl2 / 1 h 4: 40percent aq. AcOOH / 12 h View Scheme
参考文献
Heterocycles, , vol. 36, # 1 p. 149 - 155
反应条件
1: 98 percent / 1,8-diazabicyclo<5.4.0>-7-undecene (DBU) / 1,2-dichloro-ethane / 2.5 h / -10 - 20 °C 2: 87 percent / BF3*Et2O / CH2Cl2 / 72 h 3: K2CO3 / methanol / 1 h 4: pyridine, dimethylaminopyridine / CH2Cl2 / 1 h 5: 40percent aq. AcOOH / 12 h View Scheme
参考文献
Heterocycles, , vol. 36, # 1 p. 149 - 155
反应条件
1: Dowex 50W (H+) / water; 1,4-dioxane / 12 h / 50 °C 2: sodium hydroxide / isopropyl alcohol / 12 h / 20 °C 3: pyridine; 2,4,6-trichlorobenzoyl chloride / dichloromethane / 2 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 61, # 4 p. 464 - 470
反应条件
peracetic acid 12 h;
参考文献
Heterocycles, , vol. 36, # 1 p. 149 - 155
反应条件
peracetic acid; dimethylsulfide; acetic acid 1.) RT, 2 d, 2.) 1 h; Multistep reaction. Title compound not separated from byproducts;
参考文献
Heterocycles, , vol. 31, # 3 p. 423 - 426
