(4-甲基苯基)(2-吡啶基)甲酮合成路线 （共 25 条）
反应条件
caesium carbonate; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride; palladium diacetate in 1,4-dioxane
T=120°C; P=37503 Torr; 24 h;
参考文献
Maerten, Eddy; Sauthier, Mathieu; Mortreux, Andre; Castanet, Yves
Tetrahedron, 2007 , vol. 63, # 3 p. 682 - 689
反应条件
sulfur in dimethyl sulfoxide
T=80°C; 5 h;
参考文献
Shibahara, Fumitoshi; Sugiura, Rie; Yamaguchi, Eiji; Kitagawa, Asumi; Murai, Toshiaki
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3566 - 3568
反应条件
in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron, 2010 , vol. 66, # 17 p. 3135 - 3146
反应条件
potassium hydroxide in dichloromethane
3 h; Ambient temperature;
参考文献
Anders, Ernst; Markus, Fritz
Chemische Berichte, 1989 , vol. 122, p. 113 - 118
反应条件
1: TiCl4 / benzene
2: LDA / tetrahydrofuran
3: K2CO3 / methanol
4: aq. oxalic acid
5: NCS / CCl4 / 15 h / Ambient temperature
6: 76 percent / K2CO3 / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
De Kimpe, Norbert; Keppens, Marian; Fonck, Gwendolien
Chemical Communications, 1996 , # 5 p. 635 - 636
反应条件
1: NCS / CCl4 / 15 h / Ambient temperature
2: 76 percent / K2CO3 / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
De Kimpe, Norbert; Keppens, Marian; Fonck, Gwendolien
Chemical Communications, 1996 , # 5 p. 635 - 636
反应条件
1.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 °C / Inert atmosphere
View Scheme
参考文献
Hardin Narayan, Alison R.; Sarpong, Richmond
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 1 p. 70 - 78
反应条件
1.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 °C / Inert atmosphere
View Scheme
参考文献
Hardin Narayan, Alison R.; Sarpong, Richmond
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 1 p. 70 - 78
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -50 °C / Inert atmosphere
1.2: 2 h / -50 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine / o-xylene; toluene / 6 h / Inert atmosphere; Reflux
3.1: copper(l) iodide; oxygen; acetic acid / dimethyl sulfoxide / 24 h / 100 °C
View Scheme
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
反应条件
1: palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine / o-xylene; toluene / 6 h / Inert atmosphere; Reflux
2: copper(l) iodide; oxygen; acetic acid / dimethyl sulfoxide / 24 h / 100 °C
View Scheme
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
