water; triethylamine in 1,4-dioxane

sodium hydrogencarbonate in water T=20°C; 5 h;

1: 2-acetylamino-4-pentenoic acid With thermococcus litoralis L-aminoacylase; tris(hydroxymethyl)methylamine hydrochloride T=70°C; pH=8; Resolution of racemateLarge scaleEnzymatic reaction; 2: benzyl chloroformate With sodium hydroxide in tetrahydrofuran; water T=5 - 10°C; pH=7.5 - 8.5; Large scale;

1: 95 percent / aq. LiOH / 12 h / 38 °C / porcine kidney acylase I 2: aq. K2CO3 View Scheme

copper(I) bromide dimethylsulfide complex 1.) THF, 2.) -23 deg C, 2 h; Yield given. Multistep reaction;

1: 2-acetylamino-4-pentenoic acid With L-acylase T=65°C; pH=8.0; 2: benzyl chloroformate pH=8.0;

Multistep reaction.;

ammonia; sodium in tetrahydrofuran

1.1: SOCl2 2.1: lipase AY30 from Candida rugosa 2.2: K2CO3 / methanol 3.1: 83 percent / H2 / Pd/C View Scheme