7-甲氧基-4,5-二氢萘并[1,2-b]噻吩-2-羧酸合成路线 （共 4 条）
反应条件
1: With methanol; sodium hydroxide in tetrahydrofuran T=50°C; 2 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=5;
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
Location in patent: Page/Page column 9 ;
US 20120302562 A1
反应条件
1.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere 1.2: 2 h / 0 - 80 °C 2.1: ethanol; sodium / 1 h / 0 - 80 °C 3.1: sodium hydroxide; methanol / tetrahydrofuran / 2 h / 50 °C 3.2: pH 5 View Scheme
参考文献
US2012/302562 A1, ;
US 20120302562 A1
反应条件
1.1: ethanol; sodium / 1 h / 0 - 80 °C 2.1: sodium hydroxide; methanol / tetrahydrofuran / 2 h / 50 °C 2.2: pH 5 View Scheme
参考文献
US2012/302562 A1, ;
US 20120302562 A1
反应条件
potassium hydroxide; sodium hydrogencarbonate 1) ethanol, 12h, reflux 2) 30min., water-bath; Yield given. Multistep reaction;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 20, # 3 p. 243 - 244
