3-(3-三氟甲基苯基)丙醇合成路线 （共 27 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=21°C; 3 h;
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
1: 83 percent / 5 percent aq. sulfuric acid / 8 h / 75 - 80 °C 2: 82 percent / (R,R)-diethyl tartrate, titanium tetra iso-propoxide, tert-butyl hydroperoxide / CH2Cl2 / 24 h / -23 °C 3: 100 percent / hydrogen / 5 percent Pd/C / ethanol / 19 h / 20 °C 4: 87 percent / pyridine / 14.5 h / 0 °C 5: 8 percent / lithium aluminum hydride / diethyl ether / 3 h / 21 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
1: 100 percent / hydrogen / 5 percent Pd/C / ethanol / 19 h / 20 °C 2: 87 percent / pyridine / 14.5 h / 0 °C 3: 8 percent / lithium aluminum hydride / diethyl ether / 3 h / 21 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
1.1: piperidine / pyridine / 50 - 75 °C / Inert atmosphere 1.2: 0 °C / Cooling with ice 2.1: hydrogen / palladium 10 on activated carbon / methanol / 2.5 h / 750.08 Torr 3.1: borane / tetrahydrofuran / 25 h / 0 - 20 °C / Inert atmosphere View Scheme
反应条件
1: triethylamine / triphenylphosphine; copper(l) iodide; palladium dichloride / N,N-dimethyl acetamide / 50 - 70 °C / Inert atmosphere 2: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 72 h / 20 °C / 760.05 Torr View Scheme
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Journal of medicinal chemistry, , vol. 11, # 6 p. 1258 - 1262
反应条件
1: potassium methanolate / iso-xylene / 12 h / 80 °C / 760.05 Torr / Industry scale 2: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 48 h / 60 °C / 7500.75 Torr / Autoclave 3: hydrogen / / methanol / 160 °C / 150015 Torr View Scheme
反应条件
hydrogen; palladium on activated charcoal in ethanol T=19°C; P=750.06 Torr; 7 h; Yield given. Yields of byproduct given;
参考文献
Bulletin de la Societe Chimique de France, , vol. 130, p. 459 - 466
反应条件
1: 87 percent / pyridine / 14.5 h / 0 °C 2: 8 percent / lithium aluminum hydride / diethyl ether / 3 h / 21 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
1: With [{(η5-C5Me5)IrCl}2(μ-Cl)2] in toluene T=110°C; 6 h; Inert atmosphere; 2: With hydrogenchloride in diethyl ether; hexane; ethyl acetate; toluene Reagent/catalystTime;
参考文献
ZENTIVA, K.S.; VLASAKOVA Ruzena; HAJICEK Josef
Patent: WO2013/75679 A1, 2013 ;
Location in patent: Page/Page column 9 ;
