3-(3-三氟甲基苯基)丙醇合成路线 （共 27 条）
反应条件
1.1: dimethyl sulfoxide; phosphorus pentoxide / dichloromethane / 20 °C / Cooling with ice 1.2: 20 °C / Cooling with ice 2.1: sodium tris(acetoxy)borohydride; methanol / 2 h / 20 °C 3.1: hydrogenchloride / ethyl acetate; water / 1 h / 10 °C / pH 2 View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: US2011/172455 A1, 2011 ;
反应条件
hydrogen bromide in water T=85 - 90°C; 15 h;
参考文献
Beilstein Journal of Organic Chemistry, , vol. 8, p. 1366 - 1373
反应条件
sulfuric acid; hydrogen bromide in water T=25 - 55°C;
参考文献
Organic Process Research and Development, , vol. 15, # 2 p. 455 - 461
反应条件
1: 3-lt;3-(trifluoromethyl)phenylgt;propan-1-ol With 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; [bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 2 h; 2: (R)-(+)-1-(1-naphthyl)-ethylamine With sodium tris(acetoxy)borohydride in dichloromethane optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 15 p. 2990 - 3000
反应条件
1.1: dimethyl sulfoxide; phosphorus pentoxide / dichloromethane / 20 °C / Cooling with ice 1.2: 20 °C / Cooling with ice 2.1: sodium tris(acetoxy)borohydride; methanol / 2 h / 20 °C View Scheme
反应条件
1: With phosphorus pentoxide; dimethyl sulfoxide in dichloromethane T=20°C; Swern Oxidation; Cooling with ice; 2: With triethylamine in dichloromethane T=20°C; Cooling with ice;
参考文献
DIPHARMA FRANCIS s.r.l.
Patent: US2011/124917 A1, 2011 ;
Location in patent: Page/Page column 3-4 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide
T=20 - 45°C; 20 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/125026 A2, 2006 ;
Location in patent: Page/Page column 29 ;
