1: 68 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amin (TDA-1) / acetonitrile / 0.25 h / Ambient temperature 2: 83 percent / 3-chloroperbenzoic acid (70percent) / methanol / 0.5 h / Ambient temperature 3: 85 percent / NH3, MeOH / 20 h / Ambient temperature 4: 47 percent / 25percent aq. NH3, 30percent H2O2 / 24 h / 60 °C View Scheme

1: 1.) KOH, tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1) / 1.) MeCN, 40 deg C, 2.) 40 deg C, 15 min. 2: 86 percent / NH3/MeOH / 48 h / Ambient temperature 3: 1.) hydrazine, 2.) Raney-Ni / 1.) 90 deg C, 1 h, 2.) EtOH, reflux, 1 h View Scheme

1: 84 percent / NaH / tetrahydrofuran 2: 28 percent / NaOH / ethanol / Heating 3: pyridine / 24 h / Ambient temperature 4: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C 5: 5N NaOH / ethanol / 0.83 h / Heating 6: TFA / CH2Cl2 / 3 h / Ambient temperature 7: 98 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 8: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating 9: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 10: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 11: NH3 / methanol 12: 70 percent / NH3 / methanol / 12 h / 120 °C 13: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: pyridine / 24 h / Ambient temperature 2: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C 3: 5N NaOH / ethanol / 0.83 h / Heating 4: TFA / CH2Cl2 / 3 h / Ambient temperature 5: 98 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 6: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating 7: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 8: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 9: NH3 / methanol 10: 70 percent / NH3 / methanol / 12 h / 120 °C 11: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating 2: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 3: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 4: NH3 / methanol 5: 70 percent / NH3 / methanol / 12 h / 120 °C 6: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C 2: 5N NaOH / ethanol / 0.83 h / Heating 3: TFA / CH2Cl2 / 3 h / Ambient temperature 4: 98 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 5: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating 6: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 7: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 8: NH3 / methanol 9: 70 percent / NH3 / methanol / 12 h / 120 °C 10: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 70 percent / NH3 / methanol / 12 h / 120 °C 2: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 2: NH3 / methanol 3: 70 percent / NH3 / methanol / 12 h / 120 °C 4: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 2: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 3: NH3 / methanol 4: 70 percent / NH3 / methanol / 12 h / 120 °C 5: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 98 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating 3: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 4: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 5: NH3 / methanol 6: 70 percent / NH3 / methanol / 12 h / 120 °C 7: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme