3-(4-氯苯基)-1H-吡唑-5-胺合成路线 （共 6 条）
反应条件
hydrazine hydrate in ethanol T=80°C; 3 h;
参考文献
Takahashi, Toshiyuki; Sakuraba, Aya; Hirohashi, Tomoko; Shibata, Takunobu; Hirose, Masaaki; Haga, Yuji; Nonoshita, Katsumasa; Kanno, Tetsuya; Ito, Junko; Iwaasa, Hisashi; Kanatani, Akio; Fukami, Takehiro; Sato, Nagaaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 22 p. 7501 - 7511
反应条件
hydrazine hydrate in ethanol 5 h; Heating;
参考文献
Hartmann, Horst; Liebscher, Juergen
Synthesis, 1984 , # 3 p. 276 - 277
反应条件
hydrazine hydrate in ethanol 4 h; Heating;
参考文献
Nenaidenko; Golubinskii; Lenkova; Shastin; Balenkova
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 10 p. 1518 - 1520
反应条件
1.1: lithium diisopropylamide / heptane; tetrahydrofuran; ethylbenzene / 1 h / -78 °C 1.2: 74 percent / tetrahydrofuran; heptane; ethylbenzene / -78 - 20 °C 2.1: 84 percent / hydrazine monohydrate / ethanol / 3 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 22 p. 7501 - 7511
反应条件
1.1: dihydrogen peroxide; acetic acid / dichloromethane / 5 h / 45 °C 2.1: hydrazine hydrate / ethanol / 2.33 h / -5 °C / Reflux 2.2: 1 h / 55 °C View Scheme
参考文献
Heterocyclic Communications, , vol. 17, # 3-4 p. 139 - 145
反应条件
hydrogenchloride; lithium diisopropyl amide 1.) THF, RT, 2 h, 2.) THF, reflux, 5 min; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 5 p. 1549 - 1554
