3-氯-3-(4-氯苯基)丙烯腈合成路线 （共 12 条）
反应条件
Na2S*9H2O in N,N-dimethyl-formamide T=60°C; 3 h;
参考文献
Abdillahi, Ismail; Kirsch, Gilbert
Synthesis, 2011 , # 8 art. no. Z54010SS, p. 1314 - 1318
反应条件
sodium 1.) methanol or ethanol, room temp., 2.) reflux, 10 min; Yield given. Multistep reaction;
参考文献
Hartmann, Horst; Liebscher, Juergen
Synthesis, 1984 , # 3 p. 275 - 276
反应条件
sodium 1.) methanol or ethanol, room temp., 2.) reflux, 10 min; Yield given. Multistep reaction;
参考文献
Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 223 - 231
反应条件
hydrazine hydrate in ethanol 5 h; Heating;
参考文献
Hartmann, Horst; Liebscher, Juergen
Synthesis, 1984 , # 3 p. 276 - 277
反应条件
in ethanol 5 h; Heating;
参考文献
Pharmazie, , vol. 44, # 8 p. 535 - 539
反应条件
in ethanol 5 h; Heating;
参考文献
Pharmazie, , vol. 44, # 8 p. 535 - 539
反应条件
1: sodium; methanol / 0.5 h / |Reflux 2: potassium hydroxide / methanol; water / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 65, p. 223 - 231
反应条件
hydroxylamine hydrochloride; trichlorophosphate
1) 30 min, RT, 2) 30 min, 210 deg C; Yield given. Multistep reaction;
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
acetic anhydride
4 h; Heating;
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
1: With trichlorophosphate
T=60°C; 5 h;
2: With hydroxylamine hydrochloride in ethanol
3: With acetic anhydride
Reflux;
参考文献
Abdillahi, Ismail; Kirsch, Gilbert
Synthesis, 2011 , # 8 art. no. Z54010SS, p. 1314 - 1318
