3-氯-3-(4-氯苯基)丙烯腈合成路线 （共 12 条）
反应条件
1: 59 percent / H2N-OH*HCl / ethanol / Heating
2: 59 percent / acetic anhydride / 4 h / Heating
View Scheme
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
1: sodium; methanol / 0.5 h / |Reflux
2: potassium hydroxide / methanol; water / 3 h / |Reflux
3: tetrahydrofuran; toluene / 2 h / 20 °C
View Scheme
参考文献
Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 223 - 231
