3-(4-溴苯基)-3-氯丙烯腈合成路线 （共 8 条）
反应条件
hydrazine hydrate in ethanol 5 h; Heating;
参考文献
Hartmann, Horst; Liebscher, Juergen
Synthesis, 1984 , # 3 p. 276 - 277
反应条件
in ethanol 5 h; Heating;
参考文献
Bernard; Wrzeciono; Kohler; Nuhn
Pharmazie, 1989 , vol. 44, # 8 p. 535 - 539
反应条件
hydroxylamine hydrochloride; trichlorophosphate
1) 30 min, RT, 2) 30 min, 210 deg C; Yield given. Multistep reaction;
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
acetic anhydride
4 h; Heating;
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
1: 50 percent / H2N-OH*HCl / ethanol / Heating
2: 70 percent / acetic anhydride / 4 h / Heating
View Scheme
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
1: sodium; methanol / 0.5 h / |Reflux
2: potassium hydroxide / methanol; water / 3 h / |Reflux
3: tetrahydrofuran; toluene / 2 h / 20 °C
View Scheme
参考文献
Sahner, J. Henning; Brengel, Christian; Storz, Michael P.; Groh, Matthias; Plaza, Alberto; Mueller, Rolf; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8656 - 8664
反应条件
sodium
1.) methanol or ethanol, room temp., 2.) reflux, 10 min; Yield given. Multistep reaction;
参考文献
Sahner, J. Henning; Brengel, Christian; Storz, Michael P.; Groh, Matthias; Plaza, Alberto; Mueller, Rolf; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8656 - 8664
反应条件
sodium
1.) methanol or ethanol, room temp., 2.) reflux, 10 min; Yield given. Multistep reaction;
参考文献
Hartmann, Horst; Liebscher, Juergen
Synthesis, 1984 , # 3 p. 275 - 276
