反应条件
1.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C 1.2: ZnBr2 / tetrahydrofuran; diethyl ether; pentane / -78 - 0 °C 1.3: 91 percent / Cl2Pd(dppf)(CH2Cl2) / tetrahydrofuran; diethyl ether; pentane / 2 h / 23 °C 2.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C 2.2: ZnBr2 / tetrahydrofuran; diethyl ether / -78 - 0 °C 2.3: 90 percent / Cl2Pd(dppf)(CH2Cl2) / tetrahydrofuran; diethyl ether; pentane / 23 °C 3.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C 3.2: ZnBr2 / tetrahydrofuran; diethyl ether / -78 - 0 °C 3.3: 79 percent / Cl2Pd(dppf)(CH2Cl2) / tetrahydrofuran; pentane; diethyl ether / 23 °C 4.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C 4.2: ZnBr2 / tetrahydrofuran; diethyl ether / -78 - 0 °C 4.3: 83 percent / Cl2Pd(dppf)(CH2Cl2) / tetrahydrofuran; diethyl ether; pentane / 23 °C 5.1: 81 percent / KOH; H2O / methanol / 2 h / Heating 6.1: Cl2ZrCp2 / 1,2-dichloro-ethane / 8 h / 23 °C 6.2: 88 percent / I2 / tetrahydrofuran; 1,2-dichloro-ethane / 0.25 h / 0 °C 7.1: t-BuLi / diethyl ether; pentane / -78 °C 7.2: ZnBr2 / diethyl ether; tetrahydrofuran / -78 - 0 °C 7.3: Cl2Pd(dppf)(CH2Cl2) / tetrahydrofuran; diethyl ether; pentane / 23 °C 8.1: 84 percent / KOH / methanol; H2O / Heating 9.1: Cl2ZrCp2 / 1,2-dichloro-ethane / 1 h / 23 °C 9.2: 90 percent / Cl2Ni(PPh)2; n-BuLi; PPh3 / tetrahydrofuran / 1 h / 23 °C View Scheme
参考文献
Negishi, Ei-Ichi; Liou, Show-Yee; Xu, Caiding; Huo, Shouquan
Organic Letters, 2002 , vol. 4, # 2 p. 261 - 264
