4-(叔丁基二甲基硅杂氧基)-1-丁炔合成路线 （共 19 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine Substitution; Silylation;
参考文献
Yi, Jun; Lu, Xi; Sun, Yan-Yan; Xiao, Bin; Liu, Lei
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12409 - 12413
Angew. Chem., 2013 , vol. 125, # 47 p. 12635 - 12639,5
反应条件
2,6-dimethylpyridine in dichloromethane T=-78 - 20°C; 4 h;
参考文献
Jones, Graham B.; Wright, Justin M.; Hynd, George; Wyatt, Justin K.; Warner, Philip M.; Huber, Robert S.; Li, Aiwen; Kilgore, Michael W.; Sticca, Robert P.; Pollenz, Richard S.
Journal of Organic Chemistry, 2002 , vol. 67, # 16 p. 5727 - 5732
反应条件
in N,N-dimethyl-formamide
参考文献
Bristol-Myers Squibb Company
Patent: US5382592 A1, 1995 ;
US 5382592 A
反应条件
zinc trifluoromethanesulfonate; triethylamine in dichloromethane T=23°C; 12 h;
参考文献
Rahaim Jr., Ronald J.; Shaw, Jared T.
Journal of Organic Chemistry, 2008 , vol. 73, # 7 p. 2912 - 2915
反应条件
hydrogen; N1-(2-Amino-ethyl)-ethane-1,2-diamine in methanol T=25°C; 6 h;
参考文献
Yabe, Yuki; Yamada, Tsuyoshi; Nagata, Saori; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 7 p. 1264 - 1268
反应条件
triethylamine; Schwartz's reagent T=60°C; 16 h;
参考文献
Wang, Yanong D.; Kimball, Gregory; Prashad, Amar S.; Wang, Yan
Tetrahedron Letters, 2005 , vol. 46, # 50 p. 8777 - 8780
反应条件
triethylamine; Schwartz's reagent T=60°C; 16 h; Product distribution / selectivity;
参考文献
Wyeth
Patent: US2006/281943 A1, 2006 ;
Location in patent: Page/Page column 2 ;
反应条件
sodium hydrogen sulphate; silica gel in dichloromethane T=20°C; 0.5 h;
参考文献
Das, Biswanath; Reddy, K. Ravinder; Thirupathi
Tetrahedron Letters, 2006 , vol. 47, # 33 p. 5855 - 5857
反应条件
1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 30 h / 23 °C 2: NaI / acetone / 65 h / Heating 3: 1.) Mg, 2.) CuI / 1.) THF, reflux, 3 h, 2.) 30 min, ice bath, 3.) 23 deg C, 30 min View Scheme
参考文献
Oehlschlager, Allan C.; Wong, John W.; Verigin, Victor G.; Pierce, Harold D.
Journal of Organic Chemistry, 1983 , vol. 48, # 25 p. 5009 - 5017
反应条件
1: With boron tribromide in dichloromethane
T=-78 - 20°C;
2: With acetic acid in dichloromethane
T=20°C;
参考文献
Moran, Wesley J.; Morken, James P.
Organic Letters, 2006 , vol. 8, # 11 p. 2413 - 2415
