(S)-(-)-2-氨基-3-甲基-1,1-二苯基-1-丁醇合成路线 （共 20 条）
反应条件
in tetrahydrofuran; diethyl ether T=20°C; 3 h;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 15 p. 2185 - 2189
反应条件
1: bromobenzene With iodine; magnesium in tetrahydrofuran T=0°C; Inert atmosphere; 2: (L)-valine methyl ester hydrochloride in tetrahydrofuran T=0°C; 6 h; Inert atmosphere;
参考文献
ARKIVOC (Gainesville, FL, United States), , vol. 2010, # 11 p. 370 - 379,10
反应条件
1: in tetrahydrofuran T=5 - 20°C; 3.83333 h; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; water T=5 - 40°C; 0.333333 h;
参考文献
Organic Syntheses, , vol. 87, p. 26 - 35
反应条件
chiral stationary phase including (R)-naphthylethyl-carbamate-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 64 ;
反应条件
1: 2-aminoisovaleric acid With thionyl chloride in methanol T=-30 - 20°C; 2: in methanol 2 h; Heating; 3: Bromure de phenyl magnesium in tetrahydrofuran T=20°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 46, # 5 p. 863 - 865
反应条件
1: SOCl2 / methanol / 2 h / Heating 2: tetrahydrofuran View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 19 p. 3155 - 3159
反应条件
in tetrahydrofuran T=20°C;
参考文献
Tetrahedron, , vol. 57, # 23 p. 4825 - 4829
反应条件
1: bromobenzene With iodine; magnesium in diethyl ether Metallation; 2 h; Heating; 2: L-valine ethyl ester hydrochloride in diethyl ether Addition; 5 h; Heating; Further stages.;
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 20 p. 3362 - 3374
反应条件
1: 78 percent / tetrahydrofuran / Ambient temperature 2: 81 percent / 40percent aq. HF / acetonitrile View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 16 p. 4680 - 4682
反应条件
1: tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 2: hydrogenchloride / methanol / 3 h / 50 °C / |Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 8 p. 1631 - 1639
