2-苯基-4,7-二氮杂吲哚合成路线 （共 7 条）
反应条件
sodium carbonate; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
Hopkins, Corey R.; Collar, Nicola
Tetrahedron Letters, 2004 , vol. 45, # 43 p. 8087 - 8090
反应条件
1: 2-Methyl pyrazine With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: benzonitrile in tetrahydrofuran; hexane T=0 - 40°C; 4.5 h;
参考文献
EP1452525 A1, ;
Page 16 ;
反应条件
1: 2-Methyl pyrazine With lithium diisopropyl amide in tetrahydrofuran T=-40°C; 0.5 h; 2: benzonitrile in tetrahydrofuran T=-40 - 20°C;
参考文献
Mettey, Yvette; Gompel, Marie; Thomas, Virginie; Garnier, Matthieu; Leost, Maryse; Ceballos-Picot, Irene; Noble, Martin; Endicott, Jane; Vierfond, Jean-Michel; Meijer, Laurent
Journal of Medicinal Chemistry, 2003 , vol. 46, # 2 p. 222 - 236
反应条件
1: 73 percent / Et3N / Cl2Pd(PPh3)2; CuI / 1-methyl-pyrrolidin-2-one / 90 °C 2: 60 percent / KOtBu / 1-methyl-pyrrolidin-2-one / 70 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 43 p. 8087 - 8090
反应条件
lithium diisopropyl amide in tetrahydrofuran T=18°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 22, # 13 p. 1219 - 1222
反应条件
amidure de sodium in diethyl ether; ammonia 2 h;
参考文献
Tetrahedron Letters, , vol. 22, # 13 p. 1219 - 1222
反应条件
lithium diisopropyl amide 1.) THF, 30 min, 0 deg C, 2.a) THF, 0 deg C, b) 3 h, 40 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 48, # 5 p. 939 - 952
