2-(2-甲基苄基)-丙二酸合成路线 （共 7 条）
参考文献
Zhang, Xiaoyan; De Los Angeles, Joseph E.; He, Mei-Ying; Dalton, James T.; Shams, Gamal; Lei, Longping; Patil, Popat N.; Feller, Dennis R.; Miller, Duane D.; Hsu, Fu-Lian
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3014 - 3024
反应条件
1: aq. H2SO4 / 5 h / Heating 2: SOCl2 / 1 h / Heating 3: TiCl4 / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Jacobs, Stephen A.; Harvey, Ronald G.
Tetrahedron Letters, 1981 , vol. 22, p. 1093 - 1096
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
P=2585.7 Torr;
参考文献
Neustadt; Smith; Nechuta; Bronnenkant; Haslanger; Watkins; Foster; Sybertz
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2461 - 2476
反应条件
1: 62 percent / acetic acid / 4 h / 100 °C
2: 90 percent / H2 / 10percent Pd/C / ethyl acetate / 2585.7 Torr
View Scheme
参考文献
Neustadt; Smith; Nechuta; Bronnenkant; Haslanger; Watkins; Foster; Sybertz
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2461 - 2476
参考文献
Jacobs, Stephen A.; Harvey, Ronald G.
Tetrahedron Letters, 1981 , vol. 22, p. 1093 - 1096
反应条件
potassium hydroxide
1.5 h; Heating;
参考文献
Zhang, Xiaoyan; De Los Angeles, Joseph E.; He, Mei-Ying; Dalton, James T.; Shams, Gamal; Lei, Longping; Patil, Popat N.; Feller, Dennis R.; Miller, Duane D.; Hsu, Fu-Lian
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3014 - 3024
反应条件
1: 1.) EtONa / 1.) EtOH, 70 deg C, 10 min ,2.) EtOH, reflux, 2 h
2: aq. KOH / 1.5 h / Heating
View Scheme
参考文献
Zhang, Xiaoyan; De Los Angeles, Joseph E.; He, Mei-Ying; Dalton, James T.; Shams, Gamal; Lei, Longping; Patil, Popat N.; Feller, Dennis R.; Miller, Duane D.; Hsu, Fu-Lian
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3014 - 3024
