3-羟基-6,6-二甲基-1-庚烯-4-炔合成路线 （共 14 条）
反应条件
1: 3,3-dimethylbut-1-yne With lithium in tetrahydrofuran T=20 - 40°C; 50 h; 2: acrolein in tetrahydrofuran T=0 - 20°C; 4 h;
参考文献
CHEMAGIS LTD.
Patent: EP1174407 A2, 2002 ;
Location in patent: Page 6 ;
反应条件
1: ethyl bromide With iodine; magnesium in tetrahydrofuran; toluene T=45 - 50°C; 2: 3,3-dimethylbut-1-yne in tetrahydrofuran; toluene T=30 - 40°C; 4 - 6 h; 3: acrolein in tetrahydrofuran; toluene T=0 - 20°C; 5 h;
参考文献
CHEMAGIS LTD.
Patent: EP1174407 A2, 2002 ;
Location in patent: Page 5 ;
反应条件
1: 3,3-dimethylbut-1-yne; phenyl-magnesium bromide in tetrahydrofuran T=20 - 40°C; 2: acrolein in tetrahydrofuran T=0 - 20°C; 5 h;
参考文献
EP1174407 A2, ;
Page 6 ;
反应条件
1: propyl bromide With iodine; magnesium 2: 3,3-dimethylbut-1-yne 3: acrolein
参考文献
EP1174407 A2, ;
Page 5 ;
反应条件
hydrogen bromide; phosphorus tribromide; sodium carbonate 1.) EtOH, 2.) DMF, RT, overnight; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Stuetz, Anton; Petranyi, Gabor
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1539 - 1543
反应条件
1: 3-hydroxy-6,6-dimethylhept-1-ene-4-yne With hydrogenchloride; trichlorophosphate in methanol T=0 - 20°C; 20 - 24 h; 2: N-methyl-N-(1-naphthyl)methyl amine With sodium hydroxide T=80°C; 3: With hydrogenchloride in dichloromethane; water T=20°C;
参考文献
HYDEX CHEMICALS PVT LTD.
Patent: WO2005/110968 A1, 2005 ;
Location in patent: Page/Page column 9-10 ;
反应条件
hydrogenchloride; trichlorophosphate in water; acetonitrile T=10 - 28°C; 6.33333 h;
参考文献
SATYANARAYANA REDDY, Manne; RAMA SUBBA REDDY, Karamala
Patent: WO2007/96904 A2, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
thionyl chloride in hexane; N,N-dimethyl-formamide
参考文献
Sumitomo Chemical Company, Limited
Patent: US5036158 A1, 1991 ;
反应条件
boron trichloride in hexane T=20°C; Chlorination; 0.166667 h; Product distribution; Further Variations:ReagentsTemperaturesreaction time;
参考文献
AUROBINDO PHARMA LTD
Patent: WO2007/52089 A1, 2007 ;
Location in patent: Page/Page column 7 ;
参考文献
RICHTER GEDEON VEGYESZETI GYAR R.T.
Patent: EP1222160 B1, 2003 ;
