1: 1.) sodium hydride / 1.) DMF, room temp., 30 min., 2.) DMF, 50 deg C, 1.5 h. 2: 38 percent / NaBH4 / ethanol / 1.5 h / Ambient temperature 3: pyridine / CH2Cl2 / Ambient temperature 4: 386 mg / 2N NaOH / ethanol / 0.5 h / 60 °C 5: CrO3 / acetone / 1.) 5 min., 0 deg C, 2.) room temp., 15 min. 6: 89 percent / CF3CO3H, Na2HPO4 / CH2Cl2 / Ambient temperature 7: 39 percent / 2N NaOH / ethanol / 1 h / 60 °C View Scheme

1: 89 percent / CF3CO3H, Na2HPO4 / CH2Cl2 / Ambient temperature 2: 39 percent / 2N NaOH / ethanol / 1 h / 60 °C View Scheme

hydrogenchloride 240 h; Ambient temperature;