3-[(2-甲氧基-2-氧代乙基)硫代]丁酸甲酯合成路线 （共 2 条）
反应条件
piperidine
T=0°C; 15 h;
参考文献
ARRAY BIOPHARMA INC.; MITCHELL, Ian S.; BLAKE, James F.; XU, Rui; KALLAN, Nicholas C.; XIAO, Dengming; SPENCER, Keith Lee; BENCSIK, Josef R.
Patent: WO2008/6039 A1, 2008 ;
Location in patent: Page/Page column 66 ;
WO 2008/006039 A1
反应条件
1: 78 percent / Na / methanol / 0.5 h / 85 °C
2: 96 percent / NH2OH*HCl, BaCO3 / methanol / 16 h / Heating
3: 49 percent / HCl / methanol; diethyl ether / 18 h / Ambient temperature
View Scheme
参考文献
Binder; Noe; Zahora
Archiv der Pharmazie, 1981 , vol. 314, # 6 p. 557 - 564
