1-(4-氯-苯基)-环丙烷羰酰氯合成路线 （共 3 条）
反应条件
thionyl chloride
T=20°C; 1 h;
参考文献
Wu, Shengde; Fluxe, Andrew; Sheffer, Jim; Janusz, John M.; Blass, Benjamin E.; White, Ron; Jackson, Chris; Hedges, Richard; Murawsky, Michael; Fang, Bin; Fadayel, Gina M.; Hare, Michelle; Djandjighian, Laurent
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6213 - 6218
反应条件
1.1: lithium hydroxide hydrate / water / 100 °C
1.2: pH 1
2.1: oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Wasa, Masayuki; Engle, Keary M.; Lin, David W.; Yoo, Eun Jeong; Yu, Jin-Quan
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19598 - 19601
反应条件
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 50 °C
2.1: lithium hydroxide hydrate / water / 100 °C
2.2: pH 1
3.1: oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Wasa, Masayuki; Engle, Keary M.; Lin, David W.; Yoo, Eun Jeong; Yu, Jin-Quan
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19598 - 19601
