5-溴-2-氯烟酸甲酯合成路线

参考文献

Bristol-Myers Squibb Company
Patent: US2007/78140 A1, 2007 ;
Location in patent: Page/Page column 35 ;
US 20070078140 A1

67-56-1甲醇+

29241-65-45-溴-2-氯烟酸

78686-79-05-溴-2-氯烟酸甲酯

参考文献

Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.; Manka, Jason; Jacobs, Jon; Zhou, Ya; Bartolomé-Nebreda, José Manuel; Macdonald, Gregor James; Conde-Ceide, Susana; Jones, Carrie K.
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Location in patent: Page/Page column 79 ;
US 20120172391 A1

29241-65-45-溴-2-氯烟酸+

18107-18-1三甲基硅烷化重氮甲烷

78686-79-05-溴-2-氯烟酸甲酯

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENENATO, Kerry, Ellen; CHOY, Allison, Laura; HALE, Michael, Robin; HILL, Pamela; MARONE, Valerie; MILLER, Matthew
Patent: WO2010/100475 A1, 2010 ;
Location in patent: Page/Page column 87-88 ;
WO 2010/100475 A1

67-56-1甲醇+

104612-36-42-羟基-5-溴烟酸

78686-79-05-溴-2-氯烟酸甲酯

参考文献

EP1593673 A1, ;

Page/Page column 95 ;

120034-05-15-溴-2-羟基烟酸甲酯

78686-79-05-溴-2-氯烟酸甲酯

参考文献

Taylor; Wong
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3618 - 3624

10128-91-32-氧代-1,2-二氢-3-吡啶羧酸甲酯

78686-79-05-溴-2-氯烟酸甲酯

参考文献