in benzene 1 h; Heating;

ammonia in methanol; acetonitrile T=20°C; 16 h;

sodium tetrahydroborate in water T=10 - 25°C;

1.1: sodium hydrogencarbonate / acetonitrile / 0.5 h / 25 °C / |Large scale 1.2: 22 h / 20 - 34 °C / |Large scale 2.1: tetrahydrofuran / 14.25 h / 5 - 90 °C / |Inert atmosphere; |Large scale 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 4 h / 50 - 55 °C / |Inert atmosphere; |Large scale 4.1: tetrahydrofuran / 12 h / 25 - 30 °C / |Inert atmosphere; |Large scale View Scheme

1.1: sodium hydrogencarbonate / acetonitrile / 0.5 h / 25 °C / |Large scale 1.2: 22 h / 20 - 34 °C / |Large scale 2.1: tetrahydrofuran / 14.25 h / 5 - 90 °C / |Inert atmosphere; |Large scale 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 4 h / 50 - 55 °C / |Inert atmosphere; |Large scale 4.1: tetrahydrofuran / 12 h / 25 - 30 °C / |Inert atmosphere; |Large scale 5.1: palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane; potassium phosphate / toluene / 24 h / |Inert atmosphere; |Reflux View Scheme

1.1: sodium hydrogencarbonate / acetonitrile / 0.5 h / 25 °C / |Large scale 1.2: 22 h / 20 - 34 °C / |Large scale 2.1: tetrahydrofuran / 14.25 h / 5 - 90 °C / |Inert atmosphere; |Large scale 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 4 h / 50 - 55 °C / |Inert atmosphere; |Large scale View Scheme

thionyl chloride 1 h; Heating;

oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=23°C; 1 h;

sodium hydrogencarbonate in acetonitrile

thionyl chloride; N,N-dimethyl-formamide in toluene T=70 - 105°C; 7 h; Large scale;