(4-氯苯乙炔基)三甲基硅烷合成路线 （共 20 条）
反应条件
pyrrolidine; tetrabutylammomium bromide; [5-Cl-2-{(4-Cl-phenyl)-[(E)-HO-imino]methyl}phenyl-PdCl]2 in 1-methyl-pyrrolidin-2-one T=110°C; Sila-Sonogashira coupling; 2 h; Product distribution; Further Variations:ReagentsSolventsTemperaturesReaction partners;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 9-10 p. 1146 - 1158
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine Sonogashira coupling; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 2 p. 699 - 714
反应条件
2: 21 percent / n-Bu4NCl / CH2Cl2 / 72 h / Ambient temperature View Scheme
参考文献
Kataoka, Tadashi; Watanabe, Shin-ichi; Yamamoto, Keiichirou
Tetrahedron Letters, 1999 , vol. 40, # 5 p. 931 - 934
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C / |Inert atmosphere 2.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / |Inert atmosphere 2.2: 19 h / 20 °C / |Inert atmosphere View Scheme
参考文献
O'Rourke, Natasha F.; Wulff, Jeremy E.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1292 - 1308
反应条件
potassium carbonate in methanol T=25°C; 3 h;
参考文献
Wang, Yue; Huang, Bin; Sheng, Shouri; Cai, Mingzhong
Journal of Chemical Research, 2007 , # 12 p. 728 - 732
反应条件
water; triethylamine; triphenylphosphine; [RhCl(η2:η2-cycloocta-1,5-diene)]2 in tetrahydrofuran T=160°C; P=51485.6 Torr; 4 h;
参考文献
Takeuchi, Ryo; Yasue, Hiroyuki
Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5386 - 5392
反应条件
1: With cesium fluoride in dimethyl sulfoxide T=20°C; 3 h; Schlenk technique; 2: With hydrogenchloride in water T=0°C; pH=> 1;
参考文献
Yonemoto-Kobayashi, Misato; Inamoto, Kiyofumi; Tanaka, Yoshiyuki; Kondo, Yoshinori
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3773 - 3775
反应条件
1: aq. NaOH / methanol / 20 °C 2: HSiCl3 / [PtCl2(C2H4)]2 / 24 h / 20 °C 3: HSiCl3; (R)-2-bis[3,5-bis(CF3)phenyl]phosphino-1,1'-binaphthyl / [PdCl(π-C3H5)]2 / toluene / 72 h / 20 °C 4: ag. H2O2; KF; KHCO3 / tetrahydrofuran; methanol / 50 °C View Scheme
参考文献
Shimada, Toyoshi; Mukaide, Kotaro; Shinohara, Akihiro; Han, Jin Wook; Hayashi, Tamio
Journal of the American Chemical Society, 2002 , vol. 124, # 8 p. 1584 - 1585
反应条件
methyllithium; lithium bromide in tetrahydrofuran
参考文献
Morris; Wishka
Synthesis, 1994 , # 1 p. 43 - 46
反应条件
2: 84 percent / n-Bu4NI / CH2Cl2 / 24 h / Ambient temperature
View Scheme
参考文献
Kataoka, Tadashi; Watanabe, Shin-ichi; Yamamoto, Keiichirou
Tetrahedron Letters, 1999 , vol. 40, # 5 p. 931 - 934
