3-(4-联苯基)-1-丙醇合成路线 （共 20 条）
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating 2: 1.) Li, MeI / 1.) THF, -15 deg C, 45 min, 2.) -75 deg C, 24 min View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating 2: Cs-K-Na alloy / tetrahydrofuran / 0.01 h / -75 °C View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating 2: 1.) Li, MeI / 1.) THF, -15 deg C, 45 min, 2.) -75 deg C, 24 min View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating 2: 0.015 g / Cs-K-Na alloy / tetrahydrofuran / 0.01 h / -75 °C View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
hydrogen; palladium over charcoal in methanol
参考文献
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2006/20951 A1, 2006 ;
Location in patent: Page/Page column 98-100 ;
WO 2006/020951 A1
反应条件
lithium borohydride in tetrahydrofuran
T=20°C; 48 h;
参考文献
Kimball, F. Scott; Romero, F. Anthony; Ezzili, Cyrine; Garfunkle, Joie; Rayl, Thomas J.; Hochstatter, Dustin G.; Hwang, Inkyu; Boger, Dale L.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 937 - 947
反应条件
NiCl2(phenyldi(cyclohexyl)phosphine)2 in diethyl ether
T=80°C; 15 h;
参考文献
Dankwardt, John W.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 18 p. 2428 - 2432
反应条件
sodium hydroxide; lithium aluminium tetrahydride in water
参考文献
Bristol-Myers Squibb Company
Patent: US5470845 A1, 1995 ;
反应条件
2: H2 / Raney-Ni
3: LiAlH4
View Scheme
参考文献
Kigawa, Hitoshi; Takamuku, Setsuo; Toki, Susumu; Kimura, Norio; Takeda, Seishi; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 17 p. 5176 - 5179
反应条件
1: H2 / Raney-Ni
2: LiAlH4
View Scheme
参考文献
Kigawa, Hitoshi; Takamuku, Setsuo; Toki, Susumu; Kimura, Norio; Takeda, Seishi; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 17 p. 5176 - 5179
