1: carbon disulfide; bromobenzene With magnesium in tetrahydrofuran T=0°C; 1 h; 2: 2-bromo-propionic acid in tetrahydrofuran 48 h;

1: carbon disulfide; Bromure de phenyl magnesium in tetrahydrofuran 2: 2-bromo-propionic acid

sodium carbonate T=5°C; 14 h;

1: Et3N, Ac2O / 1.) 5 deg C, 1 h, 2.) -20 deg C, 1 h 2: 72 percent / xylene / 0.17 h / 105 °C 3: 91 percent / LiAlH4 / diethyl ether / 4 h / Heating 4: 84 percent / Et3N / CH2Cl2 / 24 h / Heating View Scheme