(2,4-二氧代-1,4-二氢喹唑啉-3(2H)-基)乙酸合成路线 （共 16 条）
反应条件
sodium hydroxide in methanol T=20°C; 18 h;
参考文献
Gouilleux, Laurent; Fehrentz, Jean-Alain; Winternitz; Martinez, Jean
Tetrahedron Letters, 1996 , vol. 37, # 39 p. 7031 - 7034
反应条件
sodium hydroxide in 1,4-dioxane; water T=50°C; 4 h;
参考文献
Canonne, Persephone; Akssira, Mohamed; Dahdouh, Abdelaziz; Kasmi, Hicham; Boumzebra, Mohamed
Heterocycles, 1993 , vol. 36, # 6 p. 1305 - 1314
参考文献
Takeda Chemical Industries, Inc.
Patent: US6407116 B1, 2002 ;
反应条件
hydrogenchloride in water T=100°C; 1 h;
参考文献
Papadopoulos, Eleftherios Paul
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 515 - 518
反应条件
sodium hydroxide in methanol 6 h; Ambient temperature;
参考文献
Rivero; Somanathan; Hellberg
Synthetic Communications, 1998 , vol. 28, # 11 p. 2077 - 2086
反应条件
sodium hydroxide in methanol 70 h;
参考文献
Philipova, Irena; Linden, Anthony; Heimgartner, Heinz
Helvetica Chimica Acta, 2005 , vol. 88, # 7 p. 1711 - 1733
反应条件
hydrogenchloride in water T=100°C; 0.25 h;
参考文献
Papadopoulos, Eleftherios Paul
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 515 - 518
反应条件
hydrogenchloride in water T=100°C; 0.333333 h; Yield given. Title compound not separated from byproducts;
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, p. 515 - 518
反应条件
1: N-methylmorpholine, BOP / dimethylformamide 2: 81 percent / 2 M NaOH / methanol / 18 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 39 p. 7031 - 7034
反应条件
1: Boc2O, 1M NaOH / dioxane 2: N-methylmorpholine, BOP / dimethylformamide 3: 81 percent / 2 M NaOH / methanol / 18 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 39 p. 7031 - 7034
