(2,4-二氧代-1,4-二氢喹唑啉-3(2H)-基)乙酸合成路线 （共 16 条）
反应条件
1: 88 percent / HOBt; TBTU; EtN(i-Pr)2 / acetonitrile / 4 h / 20 °C 2: 99 percent / NaOH / methanol / 70 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 88, # 7 p. 1711 - 1733
反应条件
1: 84 percent / Et3N / dimethylformamide / 2 h / 55 - 60 °C 2: 70 percent / CH2Cl2 / 1 h / Ambient temperature 3: 85 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 28, # 11 p. 2077 - 2086
反应条件
1: 70 percent / CH2Cl2 / 1 h / Ambient temperature 2: 85 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 28, # 11 p. 2077 - 2086
反应条件
1: 1.) Et3N, ethyl chloroformate, 2.) NaN3 / 1.) THF, 0 deg C, 1 h, 2.) THF, H2O, 1 h 2: 86 percent / sodium hydroxide / dioxane; H2O / 4 h / 50 °C View Scheme
参考文献
Heterocycles, , vol. 36, # 6 p. 1305 - 1314
反应条件
1: 6 h / Heating 2: 1) KOH; 2) conc. HCl / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 326, # 2 p. 342 - 348
参考文献
Justus Liebigs Annalen der Chemie, , vol. 616, p. 183,206
