4-(2-[4-(4,4,5,5-四甲基-[1,3,2]二氧硼烷)-苯氧基]-乙基)-吗啉合成路线 (共 1 条)
反应条件
1: 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid With triethylamine; isobutyl chloroformate in dichloromethane
T=-15°C; 0.0833333 h;
2: 2-(N-morpholino)ethylamine in dichloromethane
T=-15 - 20°C; 0.166667 h;
参考文献
Sugen, Inc.
Patent: US2004/220189 A1, 2004 ;
Location in patent: Page 45-46 ;
US 20040220189 A1