5-苯基甲氧基-2-吡啶甲腈合成路线 （共 2 条）
反应条件
1: 5-hydroxypyridine-2-carbonitrile With potassium carbonate in N,N-dimethyl-formamide
T=60°C; 0.5 h;
2: benzyl bromide in N,N-dimethyl-formamide
T=66°C; 1 h;
参考文献
AICURIS GMBH and CO. KG; KLENKE, Burkhard; WIEGAND, Irith; SCHIFFER, Guido; BROETZ-OESTERHELT, Heike; MAITI, Samarendra N.; KHAN, Jehangir; REDDY, Andhe; YANG, Zhixiang; HENA, Mostafa; JIA, Guofeng; LIGONG, Ou; LIANG, Hong; YIP, Judy; GAO, Chuanjun; TAJAMMUL, Sabiha; MOHAMMAD, Rahim; BISWAJEET, Ganguli
Patent: WO2013/110643 A1, 2013 ;
Location in patent: Paragraph 00482; 00483 ;
反应条件
copper(l) iodide; 1,10-phenanthroline; cesium hydrogencarbonate in toluene
T=110°C; 24 h; Inert atmosphere;
参考文献
Nara, Susheel J.; Jha, Mukund; Brinkhorst, Johan; Zemanek, Tony J.; Pratt, Derek A.
Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9326 - 9333
