25-二羟基维生素 D3-d6合成路线 （共 8 条）
反应条件
1: With triethylamine; tetrakis(triphenylphosphine) palladium(0) in toluene 2 h; Heating; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 12 h; Further stages. Title compound not separated from byproducts.;
参考文献
Analytical Chemistry, , vol. 77, # 9 p. 3001 - 3007
反应条件
1: in tetrahydrofuran; diethyl ether T=-78 - 20°C; 12 h; Darknesssolid phase reaction; 2: With water in tetrahydrofuran; diethyl ether T=0°C;
参考文献
Journal of Organic Chemistry, , vol. 74, # 13 p. 4782 - 4786
反应条件
1: 75 percent / CuI, Zn / ethanol; H2O / 0.67 h / Ambient temperature; sonicated 2: 99 percent / pyridinium dichromate 3: 89 percent / n-butyllithium / -78 °C 4: 2. tetra-n-butylammonium fluoride / 1. diethyl ether, -78 deg C, 2. THF View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 24 p. 2813 - 2816
反应条件
1: 89 percent / n-butyllithium / -78 °C 2: 2. tetra-n-butylammonium fluoride / 1. diethyl ether, -78 deg C, 2. THF View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 24 p. 2813 - 2816
反应条件
1: 99 percent / pyridinium dichromate 2: 89 percent / n-butyllithium / -78 °C 3: 2. tetra-n-butylammonium fluoride / 1. diethyl ether, -78 deg C, 2. THF View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 24 p. 2813 - 2816
反应条件
1: 89 percent / n-butyllithium / -78 °C 2: 2. tetra-n-butylammonium fluoride / 1. diethyl ether, -78 deg C, 2. THF View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 24 p. 2813 - 2816
反应条件
tetrabutyl ammonium fluoride 1. diethyl ether, -78 deg C, 2. THF; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 32, # 24 p. 2813 - 2816
反应条件
renal 1α-hydroxylase T=37°C; 1 h; incubation buffer;
参考文献
Coldwell; Traford; Varley; Kirk; Makin
Steroids, 1990 , vol. 55, # 10 p. 418 - 432
