(S)-3-(2-甲氧基苯氧基)吡咯烷合成路线 (共 2 条)
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 4 h;
参考文献
Chappie, Thomas A.; Humphrey, John M.; Allen, Martin P.; Estep, Kimberly G.; Fox, Carol B.; Lebel, Lorraine A.; Liras, Spiros; Marr, Eric S.; Menniti, Frank S.; Pandit, Jayvardhan; Schmidt, Christopher J.; Tu, Meihua; Williams, Robert D.; Yang, Feng V.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 182 - 185
反应条件
1: diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C
2: trifluoroacetic acid / CH2Cl2 / 4 h / 20 °C
View Scheme
参考文献
Chappie, Thomas A.; Humphrey, John M.; Allen, Martin P.; Estep, Kimberly G.; Fox, Carol B.; Lebel, Lorraine A.; Liras, Spiros; Marr, Eric S.; Menniti, Frank S.; Pandit, Jayvardhan; Schmidt, Christopher J.; Tu, Meihua; Williams, Robert D.; Yang, Feng V.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 182 - 185