2-氨基-5,7-二氟苯并噻唑合成路线 (共 2 条)
参考文献
Mylari; Larson; Beyer; Zembrowski; Aldinger; Dee; Siegel; Singleton
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 108 - 122
反应条件
1: With bromine in 1,2-dichloro-ethane
T=30°C; 2.5 h;
2: With ammonia in water
参考文献
Bayer Pharmaceuticals Corporation
Patent: US2004/224997 A1, 2004 ;
Location in patent: Page 31 ;