4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-醇乙酸酯合成路线 （共 13 条）
反应条件
in isopropyl alcohol 2 h; Inert atmosphereReflux;
参考文献
Ban, Hyun Seung; Tanaka, Yuko; Nabeyama, Wataru; Hatori, Masako; Nakamura, Hiroyuki
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 870 - 879
反应条件
in isopropyl alcohol T=110°C; 3 h;
参考文献
Luk, Kin-Chun; Zhang, Zhuming
Patent: US2004/254205 A1, 2004 ;
Location in patent: Page 18-19 ;
US 20040254205 A1
反应条件
1: SOCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1911 - 1914
反应条件
1: methionine; MeSO3H / 3 h / 100 °C 2: pyridine 3: SOCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1911 - 1914
反应条件
1: pyridine 2: SOCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1911 - 1914
反应条件
1: 160 - 170 °C 2: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 3: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 4: trichlorophosphate / toluene / Reflux 5: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
1: 10 palladium on activated charcoal; hydrogen 2: 160 - 170 °C 3: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 4: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 5: trichlorophosphate / toluene / Reflux 6: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 5: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 6: trichlorophosphate / toluene / Reflux 7: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen 4: 160 - 170 °C 5: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 6: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 7: trichlorophosphate / toluene / Reflux 8: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
1.1: trimethyl orthoformate / methanol / 4 h / 70 °C / |Reflux 2.1: methanesulfonic acid; dl-methionine / 3 h / 130 °C / |Cooling with ice 2.2: pH 7 3.1: pyridine / 3 h / 20 - 100 °C 4.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C 5.1: isopropyl alcohol / 5 h / 88 °C View Scheme
