N-(叔丁氧基羰基)-2-溴苯胺合成路线 （共 18 条）
反应条件
1: 1-Bromo-2-aminobenzene With sodium hydride in tetrahydrofuran 1 h; Inert atmosphereReflux; 2: di-tert-butyl dicarbonate in tetrahydrofuran 0.5 h; Inert atmosphere; 3: With sodium hydride in tetrahydrofuran Inert atmosphereReflux;
参考文献
Colobert, Francoise; Valdivia, Victoria; Choppin, Sabine; Leroux, Frederic R.; Fernandez, Inmaculada; Alvarez, Eleuterio; Khiar, Noureddine
Organic Letters, 2009 , vol. 11, # 22 p. 5130 - 5133
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; pentane T=-50°C; 3 h; 2: With carbon tetrabromide in tetrahydrofuran; pentane T=-75°C; Further stages.;
参考文献
Bellezza, Francesca; Cipiciani, Antonio; Ruzziconi, Renzo; Spizzichino, Sara
Journal of Fluorine Chemistry, 2008 , vol. 129, # 2 p. 97 - 107
反应条件
1: 1-Bromo-2-aminobenzene With lithium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.416667 h; Inert atmosphere; 2: carbonic acid di-tert-butyl ester in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Poriel, Cyril; Metivier, Remi; Rault-Berthelot, Joelle; Thirion, Damien; Barriere, Frederic; Jeannin, Olivier
Chemical Communications, 2011 , vol. 47, # 42 p. 11703 - 11705
反应条件
in 1,2-dichloro-ethane T=70°C; 60 h; Yield given;
参考文献
Journal of the American Chemical Society, , vol. 116, # 26 p. 11723 - 11736
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 16 h;
参考文献
Kessler, Albane; Coleman, Claire M.; Charoenying, Patchanee; O'Shea, Donal F.
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 7836 - 7846
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran 24 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 7836 - 7846
反应条件
1: 95 percent / 4-dimethylaminopyridine / tetrahydrofuran / 24 h / Heating 2: 6.02 g / CF3CO2H / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 7836 - 7846
反应条件
1: 50 percent / triethylamine, Pd(PPh3)2Cl2, CuI / 13 h / 100 °C 2: 1.) tert-butyllithium, 2.) 1,2-dibromoethane / 1.) Et2O, pentane, -20 deg C, 3 h, 2.) Et2O, pentane, -100 deg C to r.t., overnight 3: 77 percent / sodium ethoxide / ethanol / 2 h / Heating View Scheme
参考文献
Kondo, Yoshinori; Kojima, Satoshi; Sakamoto, Takao
Heterocycles, 1996 , vol. 43, # 12 p. 2741 - 2746
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water 20 h; Heating;
参考文献
Hogan, Anne-Marie L.; O'Shea, Donal F.
Journal of Organic Chemistry, 2007 , vol. 72, # 25 p. 9557 - 9571
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water 20 h; Heating;
参考文献
Hogan, Anne-Marie L.; O'Shea, Donal F.
Journal of Organic Chemistry, 2007 , vol. 72, # 25 p. 9557 - 9571
