2'-氟-2'-脱氧鸟苷合成路线 （共 34 条）
反应条件
ammonia T=20°C; 16 h;
参考文献
Kawasaki; Casper; Freier; Lesnik; Zounes; Cummins; Gonzalez; Cook
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 831 - 841
参考文献
US2003/225013 A1, ;
Page 18 ;
反应条件
1: DMAP / CH2Cl2 2: TBAF / tetrahydrofuran 3: Dowex-50 / methanol 4: NH4OH / 24 h / 55 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1645 - 1647
反应条件
1: Dowex-50 / methanol 2: NH4OH / 24 h / 55 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1645 - 1647
反应条件
1: TBAF / tetrahydrofuran 2: Dowex-50 / methanol 3: NH4OH / 24 h / 55 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1645 - 1647
反应条件
1: 80 percent / pyridine / 20 h / 60 °C 2: 80 percent / n-Bu4NF 3: 82 percent / p-toluenesulfonic acid / dioxane / 2 h / 23 °C 4: 78 percent / NaOH / acetonitrile; methanol; H2O 5: pyridine, (N,N-dimethylamino)pyrydine / CH2Cl2 / 1 h / 5 °C 6: tertbutylammonium fluoride / tetrahydrofuran / 5 h / 5 °C 7: 41 percent / Dowex 50W x 2-100 / methanol / 1 h / 23 °C 8: 80 percent / sat. NH3 in MeOH / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 7 p. 831 - 841
反应条件
in water 20 h; Ambient temperatureadenosine deaminase;
参考文献
Thomas; Tiwari; Clayton; Secrist III; Montgomery
Nucleosides and Nucleotides, 1994 , vol. 13, # 1-3 p. 309 - 323
反应条件
1: 23 percent / p-TsOH / 0.83 h / 160 °C / 25 Torr 2: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 3: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 4: 79 percent / MeONa / methanol / 1 h / Ambient temperature 5: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 309 - 323
反应条件
1: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 2: 79 percent / MeONa / methanol / 1 h / Ambient temperature 3: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 309 - 323
反应条件
1: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 2: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 3: 79 percent / MeONa / methanol / 1 h / Ambient temperature 4: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 309 - 323
