2'-氟-2'-脱氧鸟苷合成路线 （共 34 条）
反应条件
1: 68.6 percent / p-toluenesulfonic acid / tetrahydrofuran / 1 h / 0 °C 2: H2S / pyridine / 15 h / 90 °C 3: 69 percent / Raney Ni / dioxane; H2O / 0.67 h / Heating 4: 1.) 50percent sodium hydride in oil; 2.) trifluoromethanesulfonyl chloride; 3.) tetrabutylammonium fluoride / 1.) THF, reflux, 2 h; 2.) THF, 0 deg C, 10 min; 3.) THF, r.t., 15 h 5: 1.) conc. NH4OH; 2.) acetic acid / 1.) pyridine, 50 deg C, 3 h; 2.) H2O, 30 deg C, 2 h View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 4 p. 1034 - 1038
反应条件
1: H2S / pyridine / 15 h / 90 °C 2: 69 percent / Raney Ni / dioxane; H2O / 0.67 h / Heating 3: 1.) 50percent sodium hydride in oil; 2.) trifluoromethanesulfonyl chloride; 3.) tetrabutylammonium fluoride / 1.) THF, reflux, 2 h; 2.) THF, 0 deg C, 10 min; 3.) THF, r.t., 15 h 4: 1.) conc. NH4OH; 2.) acetic acid / 1.) pyridine, 50 deg C, 3 h; 2.) H2O, 30 deg C, 2 h View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 4 p. 1034 - 1038
反应条件
1: 69 percent / Raney Ni / dioxane; H2O / 0.67 h / Heating 2: 1.) 50percent sodium hydride in oil; 2.) trifluoromethanesulfonyl chloride; 3.) tetrabutylammonium fluoride / 1.) THF, reflux, 2 h; 2.) THF, 0 deg C, 10 min; 3.) THF, r.t., 15 h 3: 1.) conc. NH4OH; 2.) acetic acid / 1.) pyridine, 50 deg C, 3 h; 2.) H2O, 30 deg C, 2 h View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 4 p. 1034 - 1038
反应条件
1: 79 percent / pyridine / 1 h / 0 °C 2: 68.6 percent / p-toluenesulfonic acid / tetrahydrofuran / 1 h / 0 °C 3: H2S / pyridine / 15 h / 90 °C 4: 69 percent / Raney Ni / dioxane; H2O / 0.67 h / Heating 5: 1.) 50percent sodium hydride in oil; 2.) trifluoromethanesulfonyl chloride; 3.) tetrabutylammonium fluoride / 1.) THF, reflux, 2 h; 2.) THF, 0 deg C, 10 min; 3.) THF, r.t., 15 h 6: 1.) conc. NH4OH; 2.) acetic acid / 1.) pyridine, 50 deg C, 3 h; 2.) H2O, 30 deg C, 2 h View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 4 p. 1034 - 1038
反应条件
1: TsOH / dioxane 2: NaOH / pyridine; methanol 3: DMAP / CH2Cl2 4: TBAF / tetrahydrofuran 5: Dowex-50 / methanol 6: NH4OH / 24 h / 55 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1645 - 1647
反应条件
2: HF*pyridine 3: TsOH / dioxane 4: NaOH / pyridine; methanol 5: DMAP / CH2Cl2 6: TBAF / tetrahydrofuran 7: Dowex-50 / methanol 8: NH4OH / 24 h / 55 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1645 - 1647
反应条件
1: HF*pyridine 2: TsOH / dioxane 3: NaOH / pyridine; methanol 4: DMAP / CH2Cl2 5: TBAF / tetrahydrofuran 6: Dowex-50 / methanol 7: NH4OH / 24 h / 55 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1645 - 1647
反应条件
1: 79 percent / MeONa / methanol / 1 h / Ambient temperature 2: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 309 - 323
反应条件
ammonium hydroxide; acetic acid 1.) pyridine, 50 deg C, 3 h; 2.) H2O, 30 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 29, # 4 p. 1034 - 1038
反应条件
1: E. coli BMT-4D/1A 2: ADase View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 687 - 688
