N-叔-丁氧羰基3,5-二碘酪胺合成路线 （共 4 条）
反应条件
iodine cloride; N-butylamine in tetrahydrofuran
T=-35 - 0°C; 3 h;
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1: 91 percent / aq. NaHCO3 / tetrahydrofuran / 24 h
2: 92 percent / ICl; BuNH2 / tetrahydrofuran / 3 h / -35 - 0 °C
View Scheme
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1: 91 percent / aq. NaHCO3 / tetrahydrofuran / 24 h
2: 92 percent / ICl; BuNH2 / tetrahydrofuran / 3 h / -35 - 0 °C
View Scheme
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1: pyridine; copper diacetate; triethylamine / dichloromethane / |Molecular sieve
2: boron tribromide / dichloromethane / -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
ST. JUDE CHILDREN'S RESEARCH HOSPITAL; FUJII, Naoaki; ACTIS, Marcelo; PUNCHIHEWA, Chandanamali; CONNELLY, Michele; WU, Zhexiang
Patent: WO2013/6734 A1, 2013 ;
