4-氯-2-甲氧基苯甲酸甲酯合成路线 （共 8 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=75°C; 18 h;
参考文献
Capkova, Katerina; Yoneda, Yoshiyuki; Dickerson, Tobin J.; Janda, Kim D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6463 - 6466
反应条件
sulfuric acid Heating / reflux;
参考文献
Tachdjian, Catherine; Lebl-Rinnova, Marketa; Wallace, David
Patent: US2006/263411 A1, 2006 ;
Location in patent: Page/Page column 41 ;
反应条件
1: methyl 4-chloro-2-hydroxybenzoate With potassium hydroxide in methanol T=20°C; 1 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran 48 h; Inert atmosphere;
参考文献
ChemMedChem, , vol. 5, # 1 p. 65 - 78
参考文献
Chemische Berichte, , vol. 84, p. 557,561
参考文献
Kuhn; Hensel
Chemische Berichte, 1951 , vol. 84, p. 557,561
反应条件
caesium carbonate; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=120°C; 8 h;
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1555018 A1, 2005 ;
Location in patent: Page/Page column 123 ;
反应条件
lithium borohydride in tetrahydrofuran
T=60°C; 2 h;
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
