2-氨基-4H-3,1-苯并噻嗪合成路线 （共 9 条）
反应条件
1: 2-amino-benzyl alcohol With hydrogenchloride in water
T=100°C; 0.25 h;
2: thiourea in isopropyl alcohol
20 h; Heating / reflux;
3: With sodium hydroxide in water
参考文献
ROTTAPHARM S.P.A.
Patent: WO2009/40331 A2, 2009 ;
Location in patent: Page/Page column 28 ;
反应条件
ammonia; triethylamine in benzene
1.5 h; Heating;
参考文献
Gonda, Jozef; Kristian, Pavol
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 12 p. 2802 - 2809
反应条件
in isopropyl alcohol
Heating;
参考文献
Shridhar, D. R.; Rao, K. Srinivasa; Bhopale, K. K.; Tripathi, H. N.; Sai, G. S. T.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 471 - 473
反应条件
1: 56 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 1.5 h / Heating
2: 87 percent / NH3, triethylamine / benzene / 1.5 h / Heating
View Scheme
参考文献
Gonda, Jozef; Kristian, Pavol
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 12 p. 2802 - 2809
参考文献
Sharma,K.K. et al.
Journal of Organic Chemistry, 1963 , vol. 28, p. 740 - 742
反应条件
hydrogenchloride; ethanol; tin(ll) chloride
参考文献
Gabriel; Posner
Chemische Berichte, 1895 , vol. 28, p. 1027
Full Text Show Details
Cassirer
Chemische Berichte, 1892 , vol. 25, p. 3029
参考文献
Sorkin; Hinden
Helvetica Chimica Acta, 1949 , vol. 32, p. 63,66
Full Text Show Details
Beilenson; Hamer
Journal of the Chemical Society, 1942 , p. 98,101
反应条件
1: absolute alcohol
2: tin dichloride; hydrochloric acid; alcohol
View Scheme
参考文献
Cassirer
Chemische Berichte, 1892 , vol. 25, p. 3029
反应条件
hydrogenchloride; copper (I,II)-sulfite
Diazotization;
参考文献
Sorkin; Hinden
Helvetica Chimica Acta, 1949 , vol. 32, p. 63,66
