1: 2,4,5-trifluorobenzenesulfonyl chloride With sodium hydrogencarbonate; sodium sulfite in water
T=150°C; 0.111111 h; Microwave;
2: monobromoacetic acid in water
T=150°C; 0.0833333 h; Microwave;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/121110 A1, 2005 ;
Location in patent: Page/Page column 139-140 ;
WO 2005/121110 A1
potassium hydroxide in water
T=50°C; 1.) pH 9.5-10, 9 h, 2.) pH 11, overnight;
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
