反应条件
1: 3-acetyl-pyridine With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.166667 h; 2: methyl acetate in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; FRIEMAN, Bryan, A.; KALLEL, Edward, Adam; MILLER, Mark, Thomas; UY, Johnny; ZHOU, Jinglan
Patent: WO2013/109521 A1, 2013 ;
Location in patent: Paragraph 00192; 00193 ;
