(S)-2-羟基丙酸 肌乳酸合成路线 （共 142 条）
反应条件
sulfuric acid; sodium nitrite in water T=0°C; 12 h;
参考文献
Pitt, Nigel; Gani, David
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3811 - 3814
反应条件
1: With sodium hydroxide in water; ethyl acetate T=20 - 30°C; pH=9 - 10; 2: With hydrogenchloride in water pH=3.5;
参考文献
US2009/253932 A1, ;
Page/Page column 4 ;
反应条件
water; Amberlyst-36 T=130°C; 1 h;
参考文献
US2012/142945 A1, ;
Page/Page column 5 ;
反应条件
Candida antarctica lipase B; 4-nitro-phenol; MOPS buffer in water T=25°C; pH=7.2; Enzymatic reaction; Enzyme kinetics; Further Variations:Reagents;
参考文献
Journal of the American Chemical Society, , vol. 123, # 18 p. 4354 - 4355
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=0 - 20°C; 48 h; Inert atmosphere;
参考文献
Burghart-Stoll, Heike; Brueckner, Reinhard
European Journal of Organic Chemistry, 2012 , # 21 p. 3978 - 4017
反应条件
Candida utilis NBRC0988 Cupdc1Δ4-LDH2 mutant T=35°C; 33 h; Microbiological reaction;
参考文献
Ikushima, Shigehito; Fujii, Toshio; Kobayashi, Osamu; Yoshida, Satoshi; Yoshida, Aruto
Bioscience, Biotechnology and Biochemistry, 2009 , vol. 73, # 8 p. 1818 - 1824
反应条件
fructose 1,6-diphosphate (FDP) trisodium salt; nicotinamide adenine dinucleotide red. form; R171Y mutant in water T=25°C; other mutant enzyme; Rate constant;
参考文献
Journal of the American Chemical Society, , vol. 114, # 27 p. 10704 - 10710
反应条件
fructose 1,6-biphosphate; piperazine*HCl buffer; sodium formate; β-NADP+; DL-threo-1,4-dimercapto-2,3-butanediol pH 6.0, lyophilized formate dehydrogenase, lactate dehydrogenase from Bacillus stearothermophilus (BSLDH Q102R/C97G);
参考文献
Kallwass, Helmut K. W.; Luyten, Marcel A.; Parris, Wendy; Gold, Marvin; Kay, Cyril M.; Bryan Jones
Journal of the American Chemical Society, 1992 , vol. 114, # 12 p. 4551 - 4557
反应条件
potassium hydroxide; ethylenediaminetetraacetic acid; glucose-6-phosphate; 1,3-dimercapto-2-propanol; magnesium chloride T=25°C; 4 h; pH 7.8, glucose-6-phosphate dehydrogenase, D-lactic dehydrogenase, NAD+; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 103, # 16 p. 4890 - 4899
反应条件
pyruvate kinase; yeast hexokinase; nicotinamide adenine dinucleotide; lactate dehydrogenase in water T=30°C; pH=7.5; aq. phosphate bufferEnzymatic reaction; Kinetics; Concentration;
参考文献
Carbohydrate Research, , vol. 346, # 10 p. 1257 - 1261
