1: With AlCl3, aluminium chloride in dichloromethane T=-78 - 20°C; Friedel Crafts Acylation; 2: With hydrogenchloride; sodium hydroxide in water T=0°C; pH=5; 3: With hydrogenchloride in water 18 h; Heating / reflux;
参考文献
MEDIVIR AB
Patent: WO2007/6714 A1, 2007 ;
Location in patent: Page/Page column 85-86 ;