1: t-butyloxycarbonyl-L-serine With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: 5-bromo-1-pentene in N,N-dimethyl-formamide
T=20°C; 16 h;
3: methyl iodide With hydrogenchloride; water; potassium carbonate
more than 3 stages;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/64061 A1, 2008 ;
Location in patent: Page/Page column 83-84 ;
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 20 °C
1.2: 16 h / 20 °C
2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C
View Scheme
参考文献
Liu, Dejun; Dong, Jingchao; Yin, Yunxing; Ma, Rujian; Shi, Yifeng; Wu, Hao; Chen, Shuhui; Li, Ge
Chinese Journal of Chemistry, 2011 , vol. 29, # 7 p. 1489 - 1502
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 20 °C
1.2: 16 h / 20 °C
2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C
View Scheme
参考文献
Liu, Dejun; Dong, Jingchao; Yin, Yunxing; Ma, Rujian; Shi, Yifeng; Wu, Hao; Chen, Shuhui; Li, Ge
Chinese Journal of Chemistry, 2011 , vol. 29, # 7 p. 1489 - 1502
