2-丁基-4-氯-5-(羟甲基)咪唑合成路线 （共 32 条）
反应条件
1: base 2: 1.) SO2Cl2, 2.) n-Bu4NBr / 1.) CHCl3, reflux, 3 h, 2.) CHCl3, H2O, RT, 2 h 3: 6 N aq. HCl / 3 h / Heating View Scheme
参考文献
Duncia, John V.; Chiu, Andrew T.; Carini, David J.; Gregory, George B.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1312 - 1329
反应条件
1: 2-butyl-4-chloro-5-hydroxymethyl-1H-imidazole With sodium methylate in N,N-dimethyl-formamide
T=25°C; 0.5 h;
2: 2-[4-(bromomethyl)phenyl]benzonitrile in N,N-dimethyl-formamide
T=20°C; 24 h;
参考文献
Ambalavanan; Palani; Ponnuswamy; Thirumuruhan; Yathirajan; Prabhuswamy; Raju; Nagaraja; Mohana
Molecular Crystals and Liquid Crystals, 2003 , vol. 393, p. 75 - 82
