1-N-boc-2(s)-甲基-哌啶-4-酮合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran
T=50°C; P=2250.23 Torr;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94380 A1, 2004 ;
Location in patent: Page 28; 31-32 ;
WO 2004/094380 A1
反应条件
sodium hydrogencarbonate in dichloromethane; water
T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94380 A1, 2004 ;
Location in patent: Page 28; 31-32 ;
WO 2004/094380 A1
反应条件
palladium on activated charcoal; hydrogen in tetrahydrofuran; ethanol
P=775.743 Torr; 18 h;
参考文献
PFIZER INC.; Brodney, Michael Aaron; Efremov, Ivan Viktorovich; Helal, Christopher John; O'Neill, Brian Thomas
Patent: US2013/150376 A1, 2013 ;
Location in patent: Paragraph 0270 ;
反应条件
sodium hydroxide in diethyl ether; water
T=20°C; 3 h;
参考文献
Schering Corporation
Patent: US2005/4121 A1, 2005 ;
Location in patent: Page/Page column 12 ;
US 20050004121 A1
反应条件
Resolution of racemate;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94380 A1, 2004 ;
Location in patent: Page 26-27 ;
WO 2004/094380 A1
反应条件
1: tetrahydrofuran; diethyl ether / 1 h / 20 °C
2: hydrogen; palladium(II) oxide hydrate / tetrahydrofuran / 20 °C / |Inert atmosphere
View Scheme
参考文献
NOVARTIS AG; MILTZ, Wolfgang; OBERHAUSER, Berndt; VAUPEL, Andrea; VELCICKY, Juraj; WEIGAND, Klaus; LELETI, Rajender Reddy; LIU, Yugang; DU, Zhengming
Patent: US2012/252778 A1, 2012 ;
US 20120252778 A1
反应条件
sodium tetrahydroborate in ethanol
2 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94380 A1, 2004 ;
Location in patent: Page 27 ;
WO 2004/094380 A1
