(S)-(-)-2-(Boc-氨基)-3-苄氧基-1-丙醇合成路线 （共 25 条）
反应条件
borane-THF in tetrahydrofuran 1.) 0 deg C, 1 h; 2.) RT; 3.) 0 deg C, 1 h;
参考文献
Donner
Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1223 - 1226
反应条件
sodium tetrahydroborate in tetrahydrofuran; water T=-10°C; 2 h; Yield given;
参考文献
Synthetic Communications, , vol. 26, # 13 p. 2511 - 2522
反应条件
sodium tetrahydroborate in tetrahydrofuran T=0 - 20°C;
参考文献
EP1481976 A1, ;
Page 226 ;
反应条件
1: With triethylamine in tetrahydrofuran T=0 - 20°C; 0.5 h; 2: With sodium tetrahydroborate in tetrahydrofuran T=20°C; 6 h;
参考文献
EP1679296 A1, ;
Page/Page column 29 ;
反应条件
1: O-benzyl-(D)-serine With lithium aluminium tetrahydride in tetrahydrofuran 5 h; Reflux; 2: With sodium hydroxide in tetrahydrofuran; water T=20°C; 0.5 h; 3: di-tert-butyl dicarbonate in tetrahydrofuran; dichloromethane; water
参考文献
US2012/28995 A1, ;
Page/Page column 70 ;
反应条件
sodium tetrahydroborate in methanol T=-20°C;
参考文献
Aravind, Appu; Mohanty, Subhendu K.; Pratap, T. Veerabhadra; Baskaran, Sundarababu
Tetrahedron Letters, 2005 , vol. 46, # 17 p. 2965 - 2968
反应条件
sodium tetrahydroborate in tetrahydrofuran T=20°C; 0.25 h;
参考文献
Papavassilopoulou, Eleni; Christofis, Petros; Terzoglou, Despina; Moutevelis-Minakakis, Panagiota
Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8323 - 8325
反应条件
lithium borohydride in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Avenoza; Cativiela; Corzana; Peregrina; Zurbano
Synthesis, 1997 , # 10 p. 1146 - 1150
反应条件
sodium tetrahydroborate; triethanolamine in tetrahydrofuran; water; ethyl acetate
参考文献
ICN Pharmaceuticals, Inc.
Patent: US5969135 A1, 1999 ;
反应条件
1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: NaBH4 / H2O / 0 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
