(S)-(-)-2-(Boc-氨基)-3-苄氧基-1-丙醇合成路线 （共 25 条）
反应条件
1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: NaBH4 / H2O / 0 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
反应条件
1: 85 percent / CSA / methanol / 24 h / Heating 2: 93 percent / H2 / Lindlar's catalyst / methanol / 2 h / 20 °C 3: 93 percent / NaIO4/SiO2 / CH2Cl2 / 2 h / 20 °C 4: 92 percent / NaBH4 / methanol / -20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 17 p. 2965 - 2968
反应条件
1: 91 percent / NaN3 / dimethylformamide / 24 h / 110 °C 2: 85 percent / CSA / methanol / 24 h / Heating 3: 93 percent / H2 / Lindlar's catalyst / methanol / 2 h / 20 °C 4: 93 percent / NaIO4/SiO2 / CH2Cl2 / 2 h / 20 °C 5: 92 percent / NaBH4 / methanol / -20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 17 p. 2965 - 2968
反应条件
1: 93 percent / H2 / Lindlar's catalyst / methanol / 2 h / 20 °C 2: 93 percent / NaIO4/SiO2 / CH2Cl2 / 2 h / 20 °C 3: 92 percent / NaBH4 / methanol / -20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 17 p. 2965 - 2968
反应条件
1: pyridinium p-toluenesulfonate / CH2Cl2 2: LiBH4 / diethyl ether 3: NaH; TBAI / tetrahydrofuran 4: pyridinium p-toluenesulfonate / ethanol / 60 °C View Scheme
参考文献
Organic Letters, , vol. 6, # 1 p. 15 - 18
反应条件
1: LiBH4 / diethyl ether 2: NaH; TBAI / tetrahydrofuran 3: pyridinium p-toluenesulfonate / ethanol / 60 °C View Scheme
参考文献
Organic Letters, , vol. 6, # 1 p. 15 - 18
反应条件
sodium tetrahydroborate in methanol T=20°C;
参考文献
Journal of Chemical Research, , # 12 p. 683 - 685
反应条件
1: 93 percent / NaIO4/SiO2 / CH2Cl2 / 2 h / 20 °C 2: 92 percent / NaBH4 / methanol / -20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 17 p. 2965 - 2968
反应条件
1: 100 percent / Et3N / tetrahydrofuran / a) RT, 6 h, b) 50 deg C, 2 h 2: 98 percent / LiBH4 / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 1146 - 1150
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere 1.2: 25 °C / Inert atmosphere 2.1: 4-methyl-morpholine; isobutyl chloroformate / ethylene glycol dimethyl ether / -20 °C 2.2: 0.5 h / Cooling with ice View Scheme
参考文献
WO2011/69149 A2, ;
WO 2011/069149 A1
